Academic Affiliations
Education (Bioengineering):
| Ph.D. | University of Pennsylvania, 1991 |
| M.S.E. | University of Pennsylvania, 1986 |
| B.S.E. | University of Pennsylvania, 1985 |
Research:
Dr. Rabbany is currently doing research in the field of cellular and tissue engineering as applied to the vascular system. One of the major obstacles in engineering vascularized tissue is induction of endothelial vessel networks. To this end, his research applies engineering principles to the advancements being made in the differentiation of embryonic stem (ES) cells toward engineering vascularized tissue. The focus of the research is to expand pure populations of stem cells in vitro, and influence their cell fate decisions to direct differentiation into vascular cells including functional transplantable endothelial (EC) and smooth muscle (SM) cells. Understanding the mechanistic basis of ES cell differentiation into functional ECs is critical to various aspects of tissue engineering and regenerative medicine. In addition, tissue explants generated by these vascular cells can be introduced in vivo to restore function by augmenting vessel growth, in the ischemic myocardium or limbs of patients after heart attacks or diabetic vascular diseases. The projects range from elucidating the role of physical forces such as cyclic stretch, simulated microgravity, and shear stress on vascular cells and engineering of vascularized constructs. In the past, he has done research in the areas of cardiovascular Mechanics and Biosensors, and cell & receptor biomechanics.
Recent Publications:
Patents:
- Displacement Immunoassay on Porous Membrane, U.S. Patent No. 6,750,031, with Ligler and Kusterbeck, June 15, 2004.
- Displacement Immunoassay on Porous Membrane, U.S. Patent No. 6,808,937, with Ligler and Kusterbeck, October 26, 2004.
- Engineering Vascularized Networks in a Three Dimensional Physiological Structures (2010, Pending)
- Growth Factors (Angiocrine) Produced by Endothelium Supports Liver Regeneration (2010, Pending)
Contact Information:
| Hofstra University | Weill Cornell Medical College | |
| Phone: | (516) 463-6672 (Office) (516) 463-4718 (Lab) |
(212) 746-7014 (Office) (212) 746-2017 (Lab) |
| Fax: | (526) 463-4939 | (212) 746-8481 |
| Office: | 110 Weed Hall | Rm A-863 |
| Email: | sir2007@med.cornell.edu | |
| Map: | Directions to Lab | Directions to Lab |
| URL: | http://people.hofstra.edu/faculty/Sina_Y_Rabbany |
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